Individualized Stress Vulnerabilities in Manic Depressive Patients with Repeated Episodes

Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD.

OBJECTIVE Little is known about how often bipolar depressive episodes are accompanied by subsyndromal manic symptoms in bipolar I and II disorders. The authors sought to determine the frequency and clinical correlates of manic symptoms during episodes of bipolar depression. METHOD From among 4,107 enrollees in the National Institute of Mental Health's Systematic Treatment Enhancement Program ...

[Affective equivalents in depressive and manic-depressive patients].

The Use of Carbamazepine in Patients with Manic Depressive Illness

16 cases of affective disorder were studied. 8 patients received carbamazepine and 8 received either chlorpromazine or imipramine. Ratings were carried out on the Hamilton Rating Scale for Depression, Bech Rafaelsen Mania Rating scale and a side-effects symptom check list. Garbamazepine was found to be an effective treatment for affective disorders, possessing both anti-manic as well as anti-de...

Manic symptoms in patients with depressive and/or anxiety disorders.

BACKGROUND Previous studies found that patients with depressive disorders frequently have lifetime manic symptoms or even an unrecognized bipolar disorder and that these patients have more severe illness. In this study we investigated whether the presence of significant manic symptoms among patients presenting with depressive and/or anxiety disorders is associated with more severe illness, more...

Suicidality and symptoms of anxiety, irritability, and agitation in patients experiencing manic episodes with depressive symptoms: a naturalistic study

PURPOSE Patients with a bipolar I disorder (BD-I) manic episode meeting the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), criteria for "with mixed features" have a high incidence of suicide attempts and of anxiety, irritability, and agitation (AIA) symptoms. The aim of this analysis was to explore the relationship between suicidality and AIA symptoms in patients ...